The Toxicity of Gasoline Vapors Based on Knowledge of Fuel Components
نویسنده
چکیده
The toxicity of chemicals in mixtures such as gasoline may differ greatly from that observed when the chemicals are tested as pure compounds. For example, metabolic activation is the critical first step in the development of toxicity after exposure to benzene. Gasoline components inhibit benzene metabolism and thus reduce benzene's toxicity. The extent to which inhibition occurs depends on the gasoline vapor composition and inhaled concentration. Gasoline vapors vary in inhibitory effects based on the aromatic content of the mixture. Additionally, metabolic inhibition is dependent on concentration, with inhibition increasing with increasing concentration. The challenge in estimating the effect of gasoline components on the inhibition of benzene metabolism is to determine the shape of the concentration-inhibition function.
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